What if I have already taken nitrofurantoin during pregnancy? Your doctor is the best person to help you decide what is right for you and your baby. When deciding whether or not to take nitrofurantoin during pregnancy it is important to weigh up how necessary this is to your health against the possible risks to you or your baby, some of which will depend on how many weeks pregnant you are. Untreated, bladder infections can lead to infections of the kidneys (pyelonephritis), which can be dangerous for the mother and have also been linked to preterm labour. The timely and correct treatment of bladder infections during pregnancy may be crucial to the health of both mother and baby. Is it safe to use nitrofurantoin in pregnancy? Nitrofurantoin (Macrobid®) is an antibiotic used to treat infections of the bladder (also called lower urinary tract infections or UTIs). UKTIS has been providing scientific information to health care providers since 1983 on the effects that medicines, recreational drugs and chemicals may have on the developing baby during pregnancy. UKTIS is a not-for-profit organisation funded by Public Health England on behalf of UK Health Departments. First trimester exposure to nitrofurantoin was not associated with increased risk for total major congenital malformations or with specific malformations.Ĭongenital malformations nitrofurantoin pregnancy.This factsheet has been written for members of the public by the UK Teratology Information Service (UKTIS). Exposure to nitrofurantoin was not associated with increased risk of major malformations in general (adjusted OR = 0.85, 95% CI 0.67-1.08) or with specific malformations. A total of 1,329 infants and abortuses had been exposed to nitrofurantoin during the first trimester of pregnancy. Our research included a total of 105,492 pregnancies, 1,112 of which involved pregnancy terminations for medical reasons. Associations between exposure to nitrofurantoin during the first trimester and major malformations were assessed. A computerized database for medications dispensed to pregnant women in southern Israel was linked with records from the district hospital. To address these concerns, we conducted a large population-based retrospective cohort study to assess this possible association (including cases of medical terminations of pregnancy or stillbirth) and congenital malformations. While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nitrofurantoin during the first trimester of pregnancy have recently surfaced. Antibacterial drugs are among the most common medications used by pregnant women.
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